Utilizing Cinnamomum verum extract for green synthesis of silver nanoparticles: Exploring optical properties, morphology, and potential applications

Abstract

One of the most widely used medicinal herbs, cinnamon verum, has numerous pharmacological applications in traditional medicine. In this work, an aqueous extract of Cinnamomum verum (Cv) was used to produce silver nanoparticles (AgNPs). Numerous methods were used to study the Cv-AgNPs, including transmission electron microscopy(TEM), dynamic light scattering(DLS), ultraviolet–visible spectrophotometry(UV–vis), energy-dispersive spectroscopy (EDS), X-ray diffraction(XRD), and Fourier-transform infrared spectroscopy (FT-IR). The face-centered cubic(FCC) crystal structure of the Cv-AgNPs, with an average crystallite size of 19.25 nm, has been revealed by XRD pattern analysis. The MTT assay was utilized to evaluate the anti-tumor and cytotoxic effects of Cv-AgNPs on MCF-7 and HeLa cell lines. Moreover, the anticancer activity of Cv-AgNPs was demonstrated using human cervical cancer cells(HeLA) and the breast cancer cell line(MCF-7). The results showed that Cv-AgNPs demonstrate in vitro cell viability of 9 % and 6 % for Hela and MCF-7 cell line, respectively, based on 500 μl of Cv-AgNPs consumed for 24 h. This revealed the Cv-AgNPs’ potency as an anticancer agent. Taking everything into account, this work proposes an environmentally friendly way to synthesize Cv-Ag NPs, which may find use in bio-nanomedicine.

Keywords

• Green synthesis
• Cinnamomum verum
• AgNPs
• Optical properties
• MTT assay