Frontiers in Chemistry (Jul 2022)

The Chemistry of HNO: Mechanisms and Reaction Kinetics

  • Radosław Michalski,
  • Renata Smulik-Izydorczyk,
  • Jakub Pięta,
  • Monika Rola,
  • Angelika Artelska,
  • Karolina Pierzchała,
  • Jacek Zielonka,
  • Balaraman Kalyanaraman,
  • Adam Bartłomiej Sikora

DOI
https://doi.org/10.3389/fchem.2022.930657
Journal volume & issue
Vol. 10

Abstract

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Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.

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