Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe

• Jiaojiao Zhu,
• Ying Zhang,
• Ziyan Yan,
• Jianxiao Wang,
• Ping Wang,
• Xinxin Liang,
• Yuhao Liu,
• Xingkun Ao,
• Maoxiang Zhu,
• Pingkun Zhou,
• Yongqing Gu

Affiliations

Jiaojiao Zhu

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China

Ying Zhang

Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; Medical School, Shihezi University, Shihezi, Xinjiang 832003, China

Ziyan Yan

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China

Jianxiao Wang

Medical School, Shihezi University, Shihezi, Xinjiang 832003, China; Hospital of Civil Aviation University of China, Civil Aviation University of China, Tianjin 300300, China

Ping Wang

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China

Xinxin Liang

Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China

Yuhao Liu

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China

Xingkun Ao

Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China

Maoxiang Zhu

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China

Pingkun Zhou

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China; Corresponding author.

Yongqing Gu

Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China; Medical School, Shihezi University, Shihezi, Xinjiang 832003, China; Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China; Corresponding author.