Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application

Abstract

The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In this review, recent advances in the desymmetrization of symmetric dienes in the diastereotopic group differentiating reaction and its synthetic application are presented.

Keywords

• desymmetrization
• symmetric diene
• chiral auxiliary
• C2-symmetric diol
• acetal