Nature Communications (Jan 2022)
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
- Weiyi Qian,
- Tarik Hadi,
- Michele Silvestro,
- Xiao Ma,
- Cristobal F. Rivera,
- Apratim Bajpai,
- Rui Li,
- Zijing Zhang,
- Hengdong Qu,
- Rayan Sleiman Tellaoui,
- Annanina Corsica,
- Ariadne L. Zias,
- Karan Garg,
- Thomas Maldonado,
- Bhama Ramkhelawon,
- Weiqiang Chen
Affiliations
- Weiyi Qian
- Department of Mechanical and Aerospace Engineering, New York University
- Tarik Hadi
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Michele Silvestro
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Xiao Ma
- Department of Biomedical Engineering, New York University
- Cristobal F. Rivera
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Apratim Bajpai
- Department of Mechanical and Aerospace Engineering, New York University
- Rui Li
- Department of Mechanical and Aerospace Engineering, New York University
- Zijing Zhang
- Department of Mechanical and Aerospace Engineering, New York University
- Hengdong Qu
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Rayan Sleiman Tellaoui
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Annanina Corsica
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Ariadne L. Zias
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Karan Garg
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Thomas Maldonado
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Bhama Ramkhelawon
- Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center
- Weiqiang Chen
- Department of Mechanical and Aerospace Engineering, New York University
- DOI
- https://doi.org/10.1038/s41467-021-27874-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Mechanobiological signals have been reported to contribute to abdominal aortic aneurysm (AAA) development. Here the authors report that the microskeletal stiffness and a Piezo1-mediated mechanism influence vascular smooth muscle cell mechanosensation and AAA disease development.
