O3 Impact of hyperglycaemia and the therapeutic action of metformin on the length of the telomers

Abstract

Introduction: Hyperglycemia is one of the most important factors that determine the production of oxidative stress and inflammation, processes that can accelerate telomere shortening. Objectives: The objectives were to analyse the absolute telomere length (aTL) in individuals with altered fasting glucose levels (AFG) compared to individuals with normal glucose levels (NFG). To study from a prospective controlled study, the variation in aTL in patients with decompensated type 2 diabetes (T2D) before and after treatment. Materials and Methods: A population of 246 individuals of both genders was studied, which were divided into a group of individuals with blood glucose levels 50Y). A subgroup of 30 patients with newly diagnosed T2D was studied, at the beginning (T0), and at 6 months (T6) of a pharmacological treatment and hygienic-dietary measures with the objective of achieving metabolic compensation. In both studies, the biochemical-clinical variables of all individuals and the aTL were determined by quantitative real-time PCR. Statistical analyses were performed using Graph Pad Prism and SPSS software.

Keywords

• hiperglucemia
• metformina
• telómeros