Онкогематология (Sep 2014)
Invasive aspergillosis: results of multicenter study
- N. N. Klimko,
- O. V. Shadrivova,
- S. N. Khostelidi,
- E. A. Desyatik,
- Yu. V. Borzova,
- R. M. Chernopyatova,
- E. V. Shagdileeva,
- A. G. Volkova,
- M. O. Popova,
- I. S. Zyuzgin,
- O. S. Ruzhinskaya,
- O. Ye. Ryabykina,
- N. V. Medvedeva,
- A. S. Kolbin,
- E. G. Boychenko,
- T. S. Bogomolova,
- S. M. Ignatieva,
- L. S. Zubarovskaya,
- B. V. Afanasiev
Affiliations
- N. N. Klimko
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology
- O. V. Shadrivova
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- S. N. Khostelidi
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- E. A. Desyatik
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- Yu. V. Borzova
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- R. M. Chernopyatova
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- E. V. Shagdileeva
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- A. G. Volkova
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- M. O. Popova
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- I. S. Zyuzgin
- Leningrad Regional Hospital, Saint Petersburg
- O. S. Ruzhinskaya
- Leningrad Regional Hospital, Saint Petersburg
- O. Ye. Ryabykina
- Leningrad Regional Hospital, Saint Petersburg
- N. V. Medvedeva
- Municipal Hospital № 31, Saint Petersburg
- A. S. Kolbin
- Children Municipal Hospital № 1, Saint Petersburg
- E. G. Boychenko
- Children Municipal Hospital № 1, Saint Petersburg
- T. S. Bogomolova
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- S. M. Ignatieva
- P.N. Kashkin Research Institute of Medical Mycology and Department of Clinical Mycology, Allergy and Immunology I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg
- L. S. Zubarovskaya
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- B. V. Afanasiev
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- Journal volume & issue
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Vol. 9,
no. 2
pp. 13 – 19
Abstract
We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequatetherapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.
