Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Kailey A. Wyman; Adel S. Girgis; Pragnakiran S. Surapaneni; Jade M. Moore; Noura M. Abo Shama; Sara H. Mahmoud; Ahmed Mostafa; Reham F. Barghash; Zou Juan; Radha D. Dobaria; Ahmad J. Almalki; Tarek S. Ibrahim; Siva S. Panda

doi:10.3390/molecules27185923

Molecules (Sep 2022)

Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Kailey A. Wyman,
Adel S. Girgis,
Pragnakiran S. Surapaneni,
Jade M. Moore,
Noura M. Abo Shama,
Sara H. Mahmoud,
Ahmed Mostafa,
Reham F. Barghash,
Zou Juan,
Radha D. Dobaria,
Ahmad J. Almalki,
Tarek S. Ibrahim,
Siva S. Panda

Affiliations

Kailey A. Wyman: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Adel S. Girgis: Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt
Pragnakiran S. Surapaneni: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Jade M. Moore: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Noura M. Abo Shama: Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Sara H. Mahmoud: Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Ahmed Mostafa: Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Reham F. Barghash: Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt
Zou Juan: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Radha D. Dobaria: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Ahmad J. Almalki: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Tarek S. Ibrahim: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Siva S. Panda: Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA

DOI: https://doi.org/10.3390/molecules27185923
Journal volume & issue: Vol. 27, no. 18
p. 5923

Abstract

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We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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