Nature Communications (Feb 2017)
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
- Christian Büchel,
- Jan Peters,
- Tobias Banaschewski,
- Arun L. W. Bokde,
- Uli Bromberg,
- Patricia J. Conrod,
- Herta Flor,
- Dimitri Papadopoulos,
- Hugh Garavan,
- Penny Gowland,
- Andreas Heinz,
- Henrik Walter,
- Bernd Ittermann,
- Karl Mann,
- Jean-Luc Martinot,
- Marie-Laure Paillère-Martinot,
- Frauke Nees,
- Tomas Paus,
- Zdenka Pausova,
- Luise Poustka,
- Marcella Rietschel,
- Trevor W. Robbins,
- Michael N. Smolka,
- Juergen Gallinat,
- Gunter Schumann,
- Brian Knutson,
- the IMAGEN consortium
Affiliations
- Christian Büchel
- Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf
- Jan Peters
- Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Arun L. W. Bokde
- Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin
- Uli Bromberg
- Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf
- Patricia J. Conrod
- Institute of Psychiatry, King’s College London
- Herta Flor
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Dimitri Papadopoulos
- Commissariat à l’Energie Atomique et aux Energies Alternatives
- Hugh Garavan
- Institute of Neuroscience, Trinity College Dublin
- Penny Gowland
- School of Physics and Astronomy, University of Nottingham
- Andreas Heinz
- Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité—Universitätsmedizin Berlin
- Henrik Walter
- Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité—Universitätsmedizin Berlin
- Bernd Ittermann
- Physikalisch-Technische Bundesanstalt (PTB)
- Karl Mann
- Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Jean-Luc Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
- Marie-Laure Paillère-Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
- Frauke Nees
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Tomas Paus
- McGill University and Genome Quebec Innovation Centre
- Zdenka Pausova
- The Hospital for Sick Children, University of Toronto
- Luise Poustka
- Department of Child and Adolescent Psychiatry and Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Marcella Rietschel
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Trevor W. Robbins
- Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge
- Michael N. Smolka
- Department of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden
- Juergen Gallinat
- Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité—Universitätsmedizin Berlin
- Gunter Schumann
- Institute of Psychiatry, King’s College London
- Brian Knutson
- Department of Psychology, Stanford University
- the IMAGEN consortium
- DOI
- https://doi.org/10.1038/ncomms14140
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Some adolescents seek novelty, but it is unknown whether the brain circuits underlying this behaviour can be used to predict later, problematic behaviour. Here, authors show that diminished ventral striatal and prefrontal activity in response to anticipated rewards at age 14 in these individuals predicts problematic drug use at age 16.
