Frontiers in Molecular Neuroscience (Mar 2024)
Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
- Annemarie J. Carver,
- Annemarie J. Carver,
- Annemarie J. Carver,
- Benjamin Hing,
- Benjamin Hing,
- Benjamin A. Elser,
- Benjamin A. Elser,
- Benjamin A. Elser,
- Stephanie J. Lussier,
- Stephanie J. Lussier,
- Stephanie J. Lussier,
- Takehiko Yamanashi,
- Takehiko Yamanashi,
- Takehiko Yamanashi,
- Takehiko Yamanashi,
- Matthew A. Howard,
- Matthew A. Howard,
- Hiroto Kawasaki,
- Hiroto Kawasaki,
- Gen Shinozaki,
- Gen Shinozaki,
- Gen Shinozaki,
- Hanna E. Stevens,
- Hanna E. Stevens,
- Hanna E. Stevens,
- Hanna E. Stevens,
- Hanna E. Stevens
Affiliations
- Annemarie J. Carver
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Annemarie J. Carver
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Annemarie J. Carver
- Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United States
- Benjamin Hing
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Benjamin Hing
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Benjamin A. Elser
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Benjamin A. Elser
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Benjamin A. Elser
- Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, United States
- Stephanie J. Lussier
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Stephanie J. Lussier
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Stephanie J. Lussier
- Biostatistics Graduate Program, College of Public Health, University of Iowa, Iowa City, IA, United States
- Takehiko Yamanashi
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Takehiko Yamanashi
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Takehiko Yamanashi
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Standford University, Stanford, CA, United States
- Takehiko Yamanashi
- Division of Neuropsychiatry, Tottori University, Tottori, Japan
- Matthew A. Howard
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Matthew A. Howard
- Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Hiroto Kawasaki
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Hiroto Kawasaki
- Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Gen Shinozaki
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Gen Shinozaki
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Gen Shinozaki
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Standford University, Stanford, CA, United States
- Hanna E. Stevens
- Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Hanna E. Stevens
- Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Hanna E. Stevens
- Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United States
- Hanna E. Stevens
- Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, United States
- Hanna E. Stevens
- Hawk-Intellectual and Developmental Disabilities Research Center, University of Iowa, Iowa City, IA, United States
- DOI
- https://doi.org/10.3389/fnmol.2024.1303974
- Journal volume & issue
-
Vol. 17
Abstract
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery (n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR. Correlations of telomere length between tissue samples were calculated across subjects. When data were stratified by sex, saliva telomere length correlated with brain telomere length in males only. Buccal telomere length correlated with brain telomere length when males and females were combined. These findings indicate that in living subjects, telomere length in peripheral tissues variably correlates with that in brain and may be dependent on sex. Peripheral tissue telomere length may provide insight into brain telomere length, relevant to assessment of brain disorder pathophysiology.
Keywords
