Deprescribing of Inappropriately Consumed Proton Pump Inhibitors and its Clinical Consequences

Abstract

The study aimed to deprescribe inappropriate consumption among Proton Pump Inhibitor (PPI) users and assess the clinical consequences of deprescribing. This is a prospective interventional study carried out among patients aged >18 years and consuming PPI. The “potentially inappropriate” patients were counselled on harms of inappropriate PPI usage, impact of healthy dietary and lifestyle habits employing a Patient Information Leaflet (PIL). The patients deprescribed were followed up through telephonic communication. Global Overall Symptom scale (GOS) was utilized to assess gastric discomfort before and after deprescribing. From 745 patients recruited, 226 (30.33%) were classified under “potentially inappropriate”, out of which 113 (15.16%) were deprescribed. When paired t-test was applied, GOS scale indicated significant difference in symptoms before and after deprescribing (P- value<0.01). Deprescribing of PPI decreased the incidence of long-term ADR, cost burden and promotes healthy lifestyle therefore, may help improving Quality of Life (Q0L).

Keywords

• proton pump inhibitors
• deprescribing
• adverse drug reactions
• quality of life