mBio (Oct 2021)
Methylation of PhoP by CheR Regulates <i>Salmonella</i> Virulence
- Yang Su,
- Jianhui Li,
- Wenting Zhang,
- Jinjing Ni,
- Rui Huang,
- Zuoqiang Wang,
- Sen Cheng,
- Yue Wang,
- Zhixin Tian,
- Qiuxiang Zhou,
- Donghai Lin,
- Wenjuan Wu,
- Christoph M. Tang,
- Xiaoyun Liu,
- Jie Lu,
- Yu-Feng Yao
Affiliations
- Yang Su
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jianhui Li
- ORCiD
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Wenting Zhang
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jinjing Ni
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Rui Huang
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Zuoqiang Wang
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Sen Cheng
- Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
- Yue Wang
- School of Chemical Science & Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai, China
- Zhixin Tian
- School of Chemical Science & Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai, China
- Qiuxiang Zhou
- College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
- Donghai Lin
- College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
- Wenjuan Wu
- Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
- Christoph M. Tang
- Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
- Xiaoyun Liu
- Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
- Jie Lu
- ORCiD
- Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yu-Feng Yao
- ORCiD
- Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- DOI
- https://doi.org/10.1128/mBio.02099-21
- Journal volume & issue
-
Vol. 12,
no. 5
Abstract
Posttranslational modifications (PTMs) play an important role in regulating enzyme activities, protein-protein interactions, or DNA-protein recognition and, consequently, modulate many biological functions. We demonstrated that PhoP, the response regulator of PhoP/PhoQ two-component system, could be methylated on several evolutionally conserved amino acid residues.
