Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Jérôme Le Nours; T. Praveena; Daniel G. Pellicci; Nicholas A. Gherardin; Fiona J. Ross; Ricky T. Lim; Gurdyal S. Besra; Santosh Keshipeddy; Stewart K. Richardson; Amy R. Howell; Stephanie Gras; Dale I. Godfrey; Jamie Rossjohn; Adam P. Uldrich

doi:10.1038/ncomms10570

Nature Communications (Feb 2016)

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Jérôme Le Nours,
T. Praveena,
Daniel G. Pellicci,
Nicholas A. Gherardin,
Fiona J. Ross,
Ricky T. Lim,
Gurdyal S. Besra,
Santosh Keshipeddy,
Stewart K. Richardson,
Amy R. Howell,
Stephanie Gras,
Dale I. Godfrey,
Jamie Rossjohn,
Adam P. Uldrich

Affiliations

Jérôme Le Nours: Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
T. Praveena: Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Daniel G. Pellicci: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Nicholas A. Gherardin: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Fiona J. Ross: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Ricky T. Lim: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Gurdyal S. Besra: School of Biosciences, University of Birmingham
Santosh Keshipeddy: Department of Chemistry, University of Connecticut
Stewart K. Richardson: Department of Chemistry, University of Connecticut
Amy R. Howell: Department of Chemistry, University of Connecticut
Stephanie Gras: Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Dale I. Godfrey: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Jamie Rossjohn: Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Adam P. Uldrich: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne

DOI: https://doi.org/10.1038/ncomms10570
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus unveiling greater diversity in lipid antigen recognition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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