Trimodal therapy in T2‐4aN0M0 bladder cancer––How to select the best candidate?

Abstract

Abstract The reported results of trimodal treatment (TMT) in muscle‐invasive bladder cancer vary widely. We attempted to characterize the profile of ideal candidates for this approach. Between 2000 and 2019, 105 patients (median age 78 years) with T2‐4aN0M0 bladder cancer were treated with TMT and analyzed retrospectively. Mean radiotherapy dose was 62 Gy (SD 8.4). Ten pretreatment prognostic parameters were evaluated including tumor diameter on pre‐TURBT CT. Multivariate analyses was performed and combination of parameters was studied. After a median follow‐up of 29 months, 53 patients (50.5%) developed recurrence and 70 patients (67.7%) died. Death was disease‐specific in 46 patients (65.7%). Tumor diameter was the most significant prognostic parameter with p 5 cm TMT renders unacceptably poor treatment outcomes.

Keywords

• muscle‐invasive bladder cancer
• patient selection
• trimodal therapy
• tumor diameter