Nature Communications (Apr 2018)
Targeting GLP-1 receptor trafficking to improve agonist efficacy
- Ben Jones,
- Teresa Buenaventura,
- Nisha Kanda,
- Pauline Chabosseau,
- Bryn M. Owen,
- Rebecca Scott,
- Robert Goldin,
- Napat Angkathunyakul,
- Ivan R. Corrêa Jr,
- Domenico Bosco,
- Paul R. Johnson,
- Lorenzo Piemonti,
- Piero Marchetti,
- A. M. James Shapiro,
- Blake J. Cochran,
- Aylin C. Hanyaloglu,
- Asuka Inoue,
- Tricia Tan,
- Guy A. Rutter,
- Alejandra Tomas,
- Stephen R. Bloom
Affiliations
- Ben Jones
- Section of Investigative Medicine, Imperial College London
- Teresa Buenaventura
- Section of Cell Biology and Functional Genomics, Imperial College London
- Nisha Kanda
- Section of Cell Biology and Functional Genomics, Imperial College London
- Pauline Chabosseau
- Section of Cell Biology and Functional Genomics, Imperial College London
- Bryn M. Owen
- Section of Investigative Medicine, Imperial College London
- Rebecca Scott
- Section of Investigative Medicine, Imperial College London
- Robert Goldin
- Centre for Pathology, Imperial College London
- Napat Angkathunyakul
- Centre for Pathology, Imperial College London
- Ivan R. Corrêa Jr
- New England Biolabs, Inc.
- Domenico Bosco
- Department of Surgery, University of Geneva
- Paul R. Johnson
- Nuffield Department of Surgical Sciences, University of Oxford
- Lorenzo Piemonti
- Diabetes Research Institute (HSR-DRI), San Raffaele Scientific Institute
- Piero Marchetti
- Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
- A. M. James Shapiro
- Clinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta
- Blake J. Cochran
- Section of Renal and Vascular Inflammation, Imperial College London
- Aylin C. Hanyaloglu
- Department of Surgery and Cancer, Imperial College London
- Asuka Inoue
- Tohoku University
- Tricia Tan
- Section of Investigative Medicine, Imperial College London
- Guy A. Rutter
- Section of Cell Biology and Functional Genomics, Imperial College London
- Alejandra Tomas
- Section of Cell Biology and Functional Genomics, Imperial College London
- Stephen R. Bloom
- Section of Investigative Medicine, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-018-03941-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release.
