Molecular correlates of muscle spindle and Golgi tendon organ afferents

Katherine M. Oliver; Danny M. Florez-Paz; Tudor Constantin Badea; George Z. Mentis; Vilas Menon; Joriene C. de Nooij

doi:10.1038/s41467-021-21880-3

Nature Communications (Mar 2021)

Molecular correlates of muscle spindle and Golgi tendon organ afferents

Katherine M. Oliver,
Danny M. Florez-Paz,
Tudor Constantin Badea,
George Z. Mentis,
Vilas Menon,
Joriene C. de Nooij

Affiliations

Katherine M. Oliver: Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center
Danny M. Florez-Paz: Columbia University Motor Neuron Center, Columbia University Medical Center
Tudor Constantin Badea: Retinal Circuit Development and Genetics Unit, National Eye Institute
George Z. Mentis: Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center
Vilas Menon: Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center
Joriene C. de Nooij: Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center

DOI: https://doi.org/10.1038/s41467-021-21880-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Coordinated movement critically depends on sensory feedback from muscle spindles (MSs) and Golgi tendon organs (GTOs) but the afferents supplying this proprioceptive feedback have remained genetically inseparable. Here the authors use single cell transcriptome analysis to reveal the molecular basis of MS (groups Ia and II) and GTO (group Ib) afferent identities in the mouse.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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