Mechanism of FGF receptor dimerization and activation

Sarvenaz Sarabipour; Kalina Hristova

doi:10.1038/ncomms10262

Nature Communications (Jan 2016)

Mechanism of FGF receptor dimerization and activation

Sarvenaz Sarabipour,
Kalina Hristova

Affiliations

Sarvenaz Sarabipour: Department of Materials Science and Engineering, Johns Hopkins University
Kalina Hristova: Department of Materials Science and Engineering, Johns Hopkins University

DOI: https://doi.org/10.1038/ncomms10262
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Different fibroblast growth factor (fgf) ligands elicit specific biological responses, but the mechanism directing this specificity is unknown. Here the authors show that fgf1 and fgf2 impose specific reorganizations on the fgf receptor dimer trans-membrane helices that result in distinct level of receptor activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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