Alzheimer’s Research & Therapy (Dec 2020)
Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
- Susanne Röhr,
- Alexander Pabst,
- Steffi G. Riedel-Heller,
- Frank Jessen,
- Yuda Turana,
- Yvonne S. Handajani,
- Carol Brayne,
- Fiona E. Matthews,
- Blossom C. M. Stephan,
- Richard B. Lipton,
- Mindy J. Katz,
- Cuiling Wang,
- Maëlenn Guerchet,
- Pierre-Marie Preux,
- Pascal Mbelesso,
- Karen Ritchie,
- Marie-Laure Ancelin,
- Isabelle Carrière,
- Antonio Guaita,
- Annalisa Davin,
- Roberta Vaccaro,
- Ki Woong Kim,
- Ji Won Han,
- Seung Wan Suh,
- Suzana Shahar,
- Normah C. Din,
- Divya Vanoh,
- Martin van Boxtel,
- Sebastian Köhler,
- Mary Ganguli,
- Erin P. Jacobsen,
- Beth E. Snitz,
- Kaarin J. Anstey,
- Nicolas Cherbuin,
- Shuzo Kumagai,
- Sanmei Chen,
- Kenji Narazaki,
- Tze Pin Ng,
- Qi Gao,
- Xinyi Gwee,
- Henry Brodaty,
- Nicole A. Kochan,
- Julian Trollor,
- Antonio Lobo,
- Raúl López-Antón,
- Javier Santabárbara,
- John D. Crawford,
- Darren M. Lipnicki,
- Perminder S. Sachdev,
- for Cohort Studies of Memory in an International Consortium (COSMIC)
Affiliations
- Susanne Röhr
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Alexander Pabst
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Steffi G. Riedel-Heller
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Frank Jessen
- Department of Psychiatry, University of Cologne, Medical Faculty
- Yuda Turana
- Department of Neurology, School of Medicine, Atma Jaya Catholic University of Indonesia
- Yvonne S. Handajani
- Center for Health Research, School of Medicine, Atma Jaya Catholic University of Indonesia
- Carol Brayne
- Cambridge Public Health, Cambridge University
- Fiona E. Matthews
- MRC Biostatistics Unit, Institute of Public Health, Cambridge University
- Blossom C. M. Stephan
- Institute of Health and Society, Newcastle University
- Richard B. Lipton
- Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University
- Mindy J. Katz
- Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University
- Cuiling Wang
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University
- Maëlenn Guerchet
- INSERM, U1094, Tropical Neuroepidemiology
- Pierre-Marie Preux
- INSERM, U1094, Tropical Neuroepidemiology
- Pascal Mbelesso
- INSERM, U1094, Tropical Neuroepidemiology
- Karen Ritchie
- INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier
- Marie-Laure Ancelin
- INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier
- Isabelle Carrière
- INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier
- Antonio Guaita
- Golgi Cenci Foundation
- Annalisa Davin
- Golgi Cenci Foundation
- Roberta Vaccaro
- Golgi Cenci Foundation
- Ki Woong Kim
- Department of Neuropsychiatry, Seoul National University Bundang Hospital
- Ji Won Han
- Department of Neuropsychiatry, Seoul National University Bundang Hospital
- Seung Wan Suh
- Department of Psychiatry, Seoul National University College of Medicine
- Suzana Shahar
- Centre of Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia
- Normah C. Din
- Centre for Rehabilitation Science and Special Needs, Faculty of Health Science, Universiti Kebangsaan Malaysia
- Divya Vanoh
- School of Health Science, Universiti Sains Malaysia
- Martin van Boxtel
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC)
- Sebastian Köhler
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC)
- Mary Ganguli
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Erin P. Jacobsen
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Beth E. Snitz
- Department of Neurology, University of Pittsburgh School of Medicine
- Kaarin J. Anstey
- Ageing Futures Institute, University of New South Wales
- Nicolas Cherbuin
- Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National University
- Shuzo Kumagai
- Center for Health Science and Counseling, Kyushu University
- Sanmei Chen
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
- Kenji Narazaki
- Faculty of Socio-Environmental Studies, Department of Socio-Environmental Studies, Fukuoka Institute of Technology
- Tze Pin Ng
- Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Qi Gao
- Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Xinyi Gwee
- Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Henry Brodaty
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- Nicole A. Kochan
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- Julian Trollor
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- Antonio Lobo
- Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation
- Raúl López-Antón
- Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation
- Javier Santabárbara
- Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation
- John D. Crawford
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- Darren M. Lipnicki
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney
- for Cohort Studies of Memory in an International Consortium (COSMIC)
- DOI
- https://doi.org/10.1186/s13195-020-00734-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
Keywords
- Subjective cognitive decline
- Prevalence
- Epidemiology
- Individual participant data
- Data harmonization
- Cohort study
