Cytogenetic effect of Tribulus terrestris fruit aqueous extract on Chromosome Aberrations and Mitotic Index in Sorafinib treated albino male rats

Abstract

The study goal to explore the protective impact of Tribulus terrestris (Tt) aqueous extract against Sorafinib (Sor) cytotoxicity in adult male albino rats. Thrity-two rats were divided equally into eight groups and were treated orally as follows: the first control group, the 2nd group received Sorafinib, 3 rd group received Tribulus terrestris 300 with Sorafinib and 4th group received Tribulus terrestris 600 with Sorafinib group 5th received Sorafinib with Tribulus terrestris 300, group 6th received Sorafinib with Tribulus terrestris 600, group 7th received Tribulus terrestris 300 and group 8th received Tribulus terrestris 600. The dose of Tribulus terrestris was 300mg/ kg BW, 600mg/ kg BW for 4 weeks, while the dose of Sorafinib was 60 mg/ kg body weight for 3 weeks. Cytogenetic study showed significant decreasing (P<0.05) in mitotic index in Sor group and significant increasing (P<0.05) in Tribulus terrestris groups while chromosomal aberrations showed significantly increase (P<0.05) in Sorafinib group in comparison with the control group and significantly decrease (P<0.05) in Tribulus terrestris groups in comparison with the Sorafinib group. The present study demonstrated that Tribulus terrestris possesses potential cytoprotective effects against cytotoxicity caused by Sorafinib.