Nature Communications (Nov 2019)

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

  • Sue Haupt,
  • Franco Caramia,
  • Alan Herschtal,
  • Thierry Soussi,
  • Guillermina Lozano,
  • Hu Chen,
  • Han Liang,
  • Terence P. Speed,
  • Ygal Haupt

DOI
https://doi.org/10.1038/s41467-019-13266-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield against the expression of damaged X-linked genes in p53-networks. These factors likely contribute to sex-disparity.