Bronchoobstructive syndrome in bronchoectasias

Abstract

Aim. To specify mechanisms of bronchial obstruction in bronchoectasia (BE). Material and methods. Clinical, x-ray, bronchological and spirographic examinations with broncholytic test were made in 26 BE patients aged 16-66 years (14 males, 12 females). The membrane-receptor complex of erythrocytes was based on the effect of adrenoantagonist propranolol on osmotic erythrocytic resistance (obsidan test) and effect of adrenoagonist adrenalin on dynamics of ESR. Results. Allergological anamnesis was detected in 69% of BE patients, hereditary atlergological anamnesis - in 22%, membrane-receptor changes characteristic for atopic condition by obsidan test - in 46%, fractional erythrocytic sedimentation with adrenalin - in 42%. Bronchoobstruction syndrome occurred in 37% cases with mean values FEV1 46 ± 6.2%, MSVS0 17.4 ± 3%, MSV75 14.4 ± 0.9%. The broncholytic test detected a mean increment of FEV, by 12.2 ± 3.1%. Latent bronchospasm was revealed in 33% patients with BE. Conclusion. The correlation analysis suggests that among mechanisms of bronchial obstruction in bronchoectasia, bronchospasm is of great importance especially in allergological anamnesis pathogene- sis of which involves disorders of membrane-receptor complex.

Keywords

• bronchoectasia
• bronchial obstruction
• reversibility of bronchial obstruction
• atopia
• membrane- betaadrenoreceptor complex
• erythrocytes