The Evaluation of the Analgesic Effect of Hydro-Alcoholic Extract of Solanum Melongena in Syrian Mice Using Tail Flick Test

Abstract

Introduction: Nowadays, many researches are being conducted in order to evaluate the analgesic effects of different plants which have been used as sedative in traditional medicine. Solanum Melongena is a plant with different theories about its analgesic effects. In this experimental trial research, the effects of intraperitoneal(IP) injection of hydro-alcoholic extract of Solanum Melongena were assessed and compared with different doses of morphine and distilled water in Syrian mice. Methods: The effects of different doses of Solanum Melongena (1, 10, 100, and 1000µg/Kg), different doses of morphine sulfate (1, 2, and 4 µg/Kg) and distilled water on acute pain was assessed in Syrian mice. Tail flick latency after IP injection was measured for 75 minutes as the index of pain tolerance, using a tail flick apparatus which projects a condensed light stimulus on the animal's tail. Results: Our findings showed that different doses of Solanum increased analgesia index. This effect was more prominent in 45-60 minutes after IP injections which was significantly greater than the control group (p<0.05(. Conclusion: Our findings indicated that the hydro-alcoholic extract of Solanum Melongena produces analgesic effect in a dose- related manner.

Keywords

• Solanum Melongena
• Morphine
• Pain
• Pain Threshold
• Mice