Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair

Ja-Hwan Seol; Cory Holland; Xiaolei Li; Christopher Kim; Fuyang Li; Melisa Medina-Rivera; Robin Eichmiller; Ignacio F. Gallardo; Ilya J. Finkelstein; Paul Hasty; Eun Yong Shim; Jennifer A. Surtees; Sang Eun Lee

doi:10.1038/s41467-018-04327-0

Nature Communications (May 2018)

Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair

Ja-Hwan Seol,
Cory Holland,
Xiaolei Li,
Christopher Kim,
Fuyang Li,
Melisa Medina-Rivera,
Robin Eichmiller,
Ignacio F. Gallardo,
Ilya J. Finkelstein,
Paul Hasty,
Eun Yong Shim,
Jennifer A. Surtees,
Sang Eun Lee

Affiliations

Ja-Hwan Seol: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio
Cory Holland: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio
Xiaolei Li: Department of Radiation Oncology, University of Texas Health Science Center at San Antonio
Christopher Kim: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio
Fuyang Li: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio
Melisa Medina-Rivera: Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York
Robin Eichmiller: Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York
Ignacio F. Gallardo: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin
Ilya J. Finkelstein: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin
Paul Hasty: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio
Eun Yong Shim: Department of Radiation Oncology, University of Texas Health Science Center at San Antonio
Jennifer A. Surtees: Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York
Sang Eun Lee: Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-018-04327-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The yeast Rad1–Rad10 complex has multiple roles in DNA damage repair. Here the authors uncover mutants that uncouple the roles in UV excision repair and non-NER functions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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