Marine Drugs (Oct 2009)

Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms

  • Takatoshi Kawai,
  • Takashi Owa,
  • Rie Ushijima-Sugano,
  • Naomi Daikuhara,
  • Masashi Yokoya,
  • Kornvika Charupant,
  • Naoki Saito,
  • Khanit Suwanborirux

DOI
https://doi.org/10.3390/md7040483
Journal volume & issue
Vol. 7, no. 4
pp. 483 – 494

Abstract

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Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC50 values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products.

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