Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

Milica Bozic; Maite Caus; Raul R. Rodrigues-Diez; Neus Pedraza; Marta Ruiz-Ortega; Eloi Garí; Pilar Gallel; Maria José Panadés; Ana Martinez; Elvira Fernández; José Manuel Valdivielso

doi:10.1038/s41467-020-15732-9

Nature Communications (Apr 2020)

Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

Milica Bozic,
Maite Caus,
Raul R. Rodrigues-Diez,
Neus Pedraza,
Marta Ruiz-Ortega,
Eloi Garí,
Pilar Gallel,
Maria José Panadés,
Ana Martinez,
Elvira Fernández,
José Manuel Valdivielso

Affiliations

Milica Bozic: Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen Retic
Maite Caus: Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen Retic
Raul R. Rodrigues-Diez: Cellular and Molecular Biology in Renal and Vascular Pathology, IIS-Fundación Jiménez Díaz-Universidad Autónoma Madrid
Neus Pedraza: Cell Cycle, Department of Basic Medical Science, IRBLleida, University of Lleida
Marta Ruiz-Ortega: Cellular and Molecular Biology in Renal and Vascular Pathology, IIS-Fundación Jiménez Díaz-Universidad Autónoma Madrid
Eloi Garí: Cell Cycle, Department of Basic Medical Science, IRBLleida, University of Lleida
Pilar Gallel: Department of Pathology and Molecular Genetics, University Hospital Arnau de Vilanova and University of Lleida
Maria José Panadés: Department of Pathology and Molecular Genetics, University Hospital Arnau de Vilanova and University of Lleida
Ana Martinez: Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen Retic
Elvira Fernández: Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen Retic
José Manuel Valdivielso: Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen Retic

DOI: https://doi.org/10.1038/s41467-020-15732-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in protecting kidney parenchyma against injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal