Acta Cirúrgica Brasileira (Nov 2017)

Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

  • Rubens Fernando Gonçalves Ribeiro Júnior,
  • Rodrigo Paracampo Couteiro,
  • Andrew Moraes Monteiro,
  • Ivone Aline da Silva Rodrigues,
  • Lainy Carollyne da Costa Cavalcante,
  • Eduardo Henrique Herbster Gouveia,
  • Lucas Nascimento Galvão,
  • Luiz Renato Oliveira Lopes,
  • Edson Yuzur Yasojima,
  • Marcus Vinicius Henriques Brito

DOI
https://doi.org/10.1590/s0102-865020170110000006
Journal volume & issue
Vol. 32, no. 11
pp. 949 – 955

Abstract

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Abstract Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. Results: Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.

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