Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing

Huan-Ping Wang; Huan-Ping Wang; Jun-Jun He; Qiao-Yun Zhu; Lin Wang; Jian-Hu Li; Jian-Song Huang; Jian-Song Huang; Wan-Zhuo Xie; Hong-Hu Zhu; Hong-Hu Zhu; Jie Jin; Jie Jin

doi:10.3389/fonc.2021.706798

Frontiers in Oncology (Jul 2021)

Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing

Huan-Ping Wang,
Huan-Ping Wang,
Jun-Jun He,
Qiao-Yun Zhu,
Lin Wang,
Jian-Hu Li,
Jian-Song Huang,
Jian-Song Huang,
Wan-Zhuo Xie,
Hong-Hu Zhu,
Hong-Hu Zhu,
Jie Jin,
Jie Jin

Affiliations

Huan-Ping Wang: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Huan-Ping Wang: Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China
Jun-Jun He: Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Qiao-Yun Zhu: Central Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Lin Wang: Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Jian-Hu Li: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Jian-Song Huang: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Jian-Song Huang: Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China
Wan-Zhuo Xie: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Hong-Hu Zhu: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Hong-Hu Zhu: Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China
Jie Jin: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Jie Jin: Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China

DOI: https://doi.org/10.3389/fonc.2021.706798
Journal volume & issue: Vol. 11

Abstract

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The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient carrying NUP214-ABL1 fusion gene. The conventional AML chemotherapy regimen for the patient was successful. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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