Conserved long-range base pairings are associated with pre-mRNA processing of human genes

Svetlana Kalmykova; Marina Kalinina; Stepan Denisov; Alexey Mironov; Dmitry Skvortsov; Roderic Guigó; Dmitri Pervouchine

doi:10.1038/s41467-021-22549-7

Nature Communications (Apr 2021)

Conserved long-range base pairings are associated with pre-mRNA processing of human genes

Svetlana Kalmykova,
Marina Kalinina,
Stepan Denisov,
Alexey Mironov,
Dmitry Skvortsov,
Roderic Guigó,
Dmitri Pervouchine

Affiliations

Svetlana Kalmykova: Skolkovo Institute of Science and Technology
Marina Kalinina: Skolkovo Institute of Science and Technology
Stepan Denisov: Skolkovo Institute of Science and Technology
Alexey Mironov: Skolkovo Institute of Science and Technology
Dmitry Skvortsov: Faculty of Chemistry, Moscow State University
Roderic Guigó: Center for Genomic Regulation and UPF
Dmitri Pervouchine: Skolkovo Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-021-22549-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PCCR) in pre-aligned evolutionarily conserved regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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