Nature Communications (Nov 2020)
A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
Abstract
Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific targeting of ribosomes to the ER.