Nature Communications (Jun 2020)
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
- Andre L. Samson,
- Ying Zhang,
- Niall D. Geoghegan,
- Xavier J. Gavin,
- Katherine A. Davies,
- Michael J. Mlodzianoski,
- Lachlan W. Whitehead,
- Daniel Frank,
- Sarah E. Garnish,
- Cheree Fitzgibbon,
- Anne Hempel,
- Samuel N. Young,
- Annette V. Jacobsen,
- Wayne Cawthorne,
- Emma J. Petrie,
- Maree C. Faux,
- Kristy Shield-Artin,
- Najoua Lalaoui,
- Joanne M. Hildebrand,
- John Silke,
- Kelly L. Rogers,
- Guillaume Lessene,
- Edwin D. Hawkins,
- James M. Murphy
Affiliations
- Andre L. Samson
- The Walter and Eliza Hall Institute of Medical Research
- Ying Zhang
- The Walter and Eliza Hall Institute of Medical Research
- Niall D. Geoghegan
- The Walter and Eliza Hall Institute of Medical Research
- Xavier J. Gavin
- The Walter and Eliza Hall Institute of Medical Research
- Katherine A. Davies
- The Walter and Eliza Hall Institute of Medical Research
- Michael J. Mlodzianoski
- The Walter and Eliza Hall Institute of Medical Research
- Lachlan W. Whitehead
- The Walter and Eliza Hall Institute of Medical Research
- Daniel Frank
- The Walter and Eliza Hall Institute of Medical Research
- Sarah E. Garnish
- The Walter and Eliza Hall Institute of Medical Research
- Cheree Fitzgibbon
- The Walter and Eliza Hall Institute of Medical Research
- Anne Hempel
- The Walter and Eliza Hall Institute of Medical Research
- Samuel N. Young
- The Walter and Eliza Hall Institute of Medical Research
- Annette V. Jacobsen
- The Walter and Eliza Hall Institute of Medical Research
- Wayne Cawthorne
- The Walter and Eliza Hall Institute of Medical Research
- Emma J. Petrie
- The Walter and Eliza Hall Institute of Medical Research
- Maree C. Faux
- The Walter and Eliza Hall Institute of Medical Research
- Kristy Shield-Artin
- The Walter and Eliza Hall Institute of Medical Research
- Najoua Lalaoui
- The Walter and Eliza Hall Institute of Medical Research
- Joanne M. Hildebrand
- The Walter and Eliza Hall Institute of Medical Research
- John Silke
- The Walter and Eliza Hall Institute of Medical Research
- Kelly L. Rogers
- The Walter and Eliza Hall Institute of Medical Research
- Guillaume Lessene
- The Walter and Eliza Hall Institute of Medical Research
- Edwin D. Hawkins
- The Walter and Eliza Hall Institute of Medical Research
- James M. Murphy
- The Walter and Eliza Hall Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-020-16887-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.
