Role of SphK/S1P in cardiovascular diseases

Abstract

Sphingosine-1-phosphate (S1P) is a highly active membrane phospholipid metabolite with important physiological roles in the cardiovascular system. Sphingosine kinase (SphK) is a lipase that is important for maintaining stable S1P levels in vivo. S1P exerts different physiological effects in cardiovascular diseases by catalytically regulating the binding of S1P to G protein-coupled receptors (S1PR1-5) on the cell surface, thus exerting different physiological effects in cardiovascular diseases.For example, they are involved in regulating the development of diseases such as atherosclerosis, myocardial ischemia-reperfusion injury, myocardial infarction, heart failure and other diseases, maintaining the barrier function of vascular endothelial cells, protecting the endothelial glycocalyx layer, leukocyte adhesion, inflammatory reactions and other pathophysiologic processes.

Keywords

• sphingosine-1-phosphate|sphingosine kinase|cardiovascular diseases|endothelial glycocalyx layer