Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

Jing Yang; Wei Yin; Richard Van; Keyi Yin; Peng Wang; Chao Zheng; Biyue Zhu; Kathleen Ran; Can Zhang; Mohanraja Kumar; Yihan Shao; Chongzhao Ran

doi:10.1038/s41467-020-17783-4

Nature Communications (Aug 2020)

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

Jing Yang,
Wei Yin,
Richard Van,
Keyi Yin,
Peng Wang,
Chao Zheng,
Biyue Zhu,
Kathleen Ran,
Can Zhang,
Mohanraja Kumar,
Yihan Shao,
Chongzhao Ran

Affiliations

Jing Yang: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Wei Yin: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Richard Van: Department of Chemistry and Biochemistry, University of Oklahoma
Keyi Yin: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Peng Wang: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Chao Zheng: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Biyue Zhu: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Kathleen Ran: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown
Can Zhang: Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Mohanraja Kumar: Department of Chemistry, Massachusetts Institute of Technology
Yihan Shao: Department of Chemistry and Biochemistry, University of Oklahoma
Chongzhao Ran: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown

DOI: https://doi.org/10.1038/s41467-020-17783-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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