Nature Communications (Feb 2023)
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
- Ronja Mothes,
- Anna Pascual-Reguant,
- Ralf Koehler,
- Juliane Liebeskind,
- Alina Liebheit,
- Sandy Bauherr,
- Lars Philipsen,
- Carsten Dittmayer,
- Michael Laue,
- Regina von Manitius,
- Sefer Elezkurtaj,
- Pawel Durek,
- Frederik Heinrich,
- Gitta A. Heinz,
- Gabriela M. Guerra,
- Benedikt Obermayer,
- Jenny Meinhardt,
- Jana Ihlow,
- Josefine Radke,
- Frank L. Heppner,
- Philipp Enghard,
- Helena Stockmann,
- Tom Aschman,
- Julia Schneider,
- Victor M. Corman,
- Leif E. Sander,
- Mir-Farzin Mashreghi,
- Thomas Conrad,
- Andreas C. Hocke,
- Raluca A. Niesner,
- Helena Radbruch,
- Anja E. Hauser
Affiliations
- Ronja Mothes
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Anna Pascual-Reguant
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Ralf Koehler
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Juliane Liebeskind
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Alina Liebheit
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Sandy Bauherr
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Lars Philipsen
- Institute of Molecular and Clinical Immunology, Medical Center, Otto-von-Guericke University Magdeburg
- Carsten Dittmayer
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Michael Laue
- Centre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute
- Regina von Manitius
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Sefer Elezkurtaj
- Institute of Pathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Pawel Durek
- Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Frederik Heinrich
- Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Gitta A. Heinz
- Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Gabriela M. Guerra
- Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Benedikt Obermayer
- Core Unit Bioinformatics (CUBI), Berlin Institute of Health at Charité-Universitätsmedizin Berlin
- Jenny Meinhardt
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Jana Ihlow
- Institute of Pathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Josefine Radke
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Frank L. Heppner
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Philipp Enghard
- Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Helena Stockmann
- Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Tom Aschman
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Julia Schneider
- Institute of Virology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin and German Centre for Infection Research
- Victor M. Corman
- Institute of Virology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin and German Centre for Infection Research
- Leif E. Sander
- Berlin Institute of Health (BIH)
- Mir-Farzin Mashreghi
- Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- Thomas Conrad
- Genomics Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Andreas C. Hocke
- Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin and German Center for Lung Research (DZL)
- Raluca A. Niesner
- Dynamic and Functional in vivo Imaging, Veterinary Medicine, Freie Universität Berlin
- Helena Radbruch
- Department of Neuropathology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Anja E. Hauser
- Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute
- DOI
- https://doi.org/10.1038/s41467-023-36333-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Infection with SARS-CoV-2 has been linked with substantive inflammation, lung pathology and development of COVID-19. Here the authors spatially associate CCL18 and CCL21 in distinct tissue niches with lung pathology of severe COVID-19.
