Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity

Abstract

Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of human AML with gene expression profile suggesting T-lymphoid origin and potentially novel treatment.

Keywords

• leukemia
• lineage plasticity
• myeloid differentiation
• t-cell progenitors