Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Marcos Díaz-Fernández; Manuel Algarra; Saturnino Calvo-Losada; José-Joaquín Quirante; Francisco Sarabia; María-Soledad Pino-González

doi:10.3390/molecules29163864

Molecules (Aug 2024)

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Marcos Díaz-Fernández,
Manuel Algarra,
Saturnino Calvo-Losada,
José-Joaquín Quirante,
Francisco Sarabia,
María-Soledad Pino-González

Affiliations

Marcos Díaz-Fernández: Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain
Manuel Algarra: Department of Science, INAMAT2-Institute for Advanced Materials and Mathematics, Public University of Navarra, 31006 Pamplona, Spain
Saturnino Calvo-Losada: Department of Physical Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain
José-Joaquín Quirante: Department of Physical Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain
Francisco Sarabia: Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain
María-Soledad Pino-González: Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain

DOI: https://doi.org/10.3390/molecules29163864
Journal volume & issue: Vol. 29, no. 16
p. 3864

Abstract

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The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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