Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Wei Wei; Alistair T. Pagnamenta; Nicholas Gleadall; Alba Sanchis-Juan; Jonathan Stephens; John Broxholme; Salih Tuna; Christopher A. Odhams; Genomics England Research Consortium; NIHR BioResource; Carl Fratter; Ernest Turro; Mark J. Caulfield; Jenny C. Taylor; Shamima Rahman; Patrick F. Chinnery

doi:10.1038/s41467-020-15336-3

Nature Communications (Apr 2020)

Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Wei Wei,
Alistair T. Pagnamenta,
Nicholas Gleadall,
Alba Sanchis-Juan,
Jonathan Stephens,
John Broxholme,
Salih Tuna,
Christopher A. Odhams,
Genomics England Research Consortium,
NIHR BioResource,
Carl Fratter,
Ernest Turro,
Mark J. Caulfield,
Jenny C. Taylor,
Shamima Rahman,
Patrick F. Chinnery

Affiliations

Wei Wei: Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus
Alistair T. Pagnamenta: Wellcome Centre for Human Genetics, University of Oxford
Nicholas Gleadall: Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
Alba Sanchis-Juan: Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
Jonathan Stephens: Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
John Broxholme: Wellcome Centre for Human Genetics, University of Oxford
Salih Tuna: Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
Christopher A. Odhams: Genomics England
Genomics England Research Consortium
NIHR BioResource
Carl Fratter: Oxford Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital
Ernest Turro: Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
Mark J. Caulfield: Genomics England
Jenny C. Taylor: Wellcome Centre for Human Genetics, University of Oxford
Shamima Rahman: Metabolic Department, Great Ormond Street Hospital for Children NHS Foundation Trust
Patrick F. Chinnery: Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus

DOI: https://doi.org/10.1038/s41467-020-15336-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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