Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Laura A. Laviolette; Julien Mermoud; Isabel A. Calvo; Nicholas Olson; Myriam Boukhali; Ortrud K. Steinlein; Elisabeth Roider; Elke C. Sattler; Dachuan Huang; Bin Tean Teh; Mo Motamedi; Wilhelm Haas; Othon Iliopoulos

doi:10.1038/ncomms15866

Nature Communications (Jun 2017)

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Laura A. Laviolette,
Julien Mermoud,
Isabel A. Calvo,
Nicholas Olson,
Myriam Boukhali,
Ortrud K. Steinlein,
Elisabeth Roider,
Elke C. Sattler,
Dachuan Huang,
Bin Tean Teh,
Mo Motamedi,
Wilhelm Haas,
Othon Iliopoulos

Affiliations

Laura A. Laviolette: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Julien Mermoud: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Isabel A. Calvo: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Nicholas Olson: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Myriam Boukhali: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Ortrud K. Steinlein: Institute of Human Genetics, University Hospital Munich, University of Munich
Elisabeth Roider: Department of Dermatology and Allergology, University Hospital, Ludwig Maximilian University Munich
Elke C. Sattler: Department of Dermatology and Allergology, University Hospital, Ludwig Maximilian University Munich
Dachuan Huang: Division of Medical Sciences, Laboratory of Cancer Epigenome, National Cancer Centre Singapore
Bin Tean Teh: Division of Medical Sciences, Laboratory of Cancer Epigenome, National Cancer Centre Singapore
Mo Motamedi: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Wilhelm Haas: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School
Othon Iliopoulos: Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School

DOI: https://doi.org/10.1038/ncomms15866
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal