Analytical methods for quantification of non-steroidal anti-inflammatory drugs in pharmaceutical and biological samples: An overview of developments in the last decade

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used pharmaceuticals in both human and animal medicines for the treatment of certain conditions such as inflammation, fever, and pain. The role of validated analytical methods has become highly important in the quantification of drug substances from their pharmaceuticals as precise product quality control is required. In the present review, we have summarized various sample preparation methods and analytical methods developed for the quantification of NSAIDs during the past decade (2012-till date). Furthermore, an in-depth description of numerous techniques including chromatography (89), UV spectrophotometry (5), spectroflurometry (4), IR spectroscopy (3), electrophoresis (4), and electrochemical (9) approaches used to determine and quantify NSAIDs are provided. Based on the matrix utilized, the following details were discussed: analytical conditions, detection limits, and solvent used in sample preparation. The present compilation provides valuable insights and crucial information on quantification methods for NSAIDs and would assist the scientific community to select the best and economical method for drug analysis in pharmaceuticals and biological samples.

Keywords

• NSAIDs
• Sample preparation
• Analytical methods
• Spectroscopy
• Chromatography
• Electrochemical techniques