Nature Communications (Oct 2020)
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
- Astrid De Boeck,
- Bo Young Ahn,
- Charlotte D’Mello,
- Xueqing Lun,
- Shyam V. Menon,
- Mana M. Alshehri,
- Frank Szulzewsky,
- Yaoqing Shen,
- Lubaba Khan,
- Ngoc Ha Dang,
- Elliott Reichardt,
- Kimberly-Ann Goring,
- Jennifer King,
- Cameron J. Grisdale,
- Natalie Grinshtein,
- Dolores Hambardzumyan,
- Karlyne M. Reilly,
- Michael D. Blough,
- J. Gregory Cairncross,
- V. Wee Yong,
- Marco A. Marra,
- Steven J. M. Jones,
- David R. Kaplan,
- Kathy D. McCoy,
- Eric C. Holland,
- Pinaki Bose,
- Jennifer A. Chan,
- Stephen M. Robbins,
- Donna L. Senger
Affiliations
- Astrid De Boeck
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Bo Young Ahn
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Charlotte D’Mello
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Xueqing Lun
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Shyam V. Menon
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Mana M. Alshehri
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Frank Szulzewsky
- Divison of Human Biology, Fred Hutchinson Cancer Research Center
- Yaoqing Shen
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Lubaba Khan
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Ngoc Ha Dang
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Elliott Reichardt
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Kimberly-Ann Goring
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Jennifer King
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Cameron J. Grisdale
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Natalie Grinshtein
- Department of Molecular Genetics, University of Toronto and Program in Neurosciences and Mental Health, Hospital for Sick Children
- Dolores Hambardzumyan
- Department of Oncological Sciences, The Tisch Cancer Institute and the Department of Neurosurgery, Icahn School of Medicine at Mount Sinai
- Karlyne M. Reilly
- Center for Cancer Research, National Cancer Institute
- Michael D. Blough
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- J. Gregory Cairncross
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- V. Wee Yong
- Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Steven J. M. Jones
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- David R. Kaplan
- Department of Molecular Genetics, University of Toronto and Program in Neurosciences and Mental Health, Hospital for Sick Children
- Kathy D. McCoy
- Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
- Eric C. Holland
- Divison of Human Biology, Fred Hutchinson Cancer Research Center
- Pinaki Bose
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Jennifer A. Chan
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Stephen M. Robbins
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- Donna L. Senger
- Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
- DOI
- https://doi.org/10.1038/s41467-020-18569-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 24
Abstract
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.
