Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles

Tudor Braniste; Vitalie Cobzac; Polina Ababii; Irina Plesco; Simion Raevschi; Alexandru Didencu; Mihail Maniuc; Viorel Nacu; Ion Ababii; Ion Tiginyanu

Biotechnology Reports (Mar 2020)

Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles

Tudor Braniste,
Vitalie Cobzac,
Polina Ababii,
Irina Plesco,
Simion Raevschi,
Alexandru Didencu,
Mihail Maniuc,
Viorel Nacu,
Ion Ababii,
Ion Tiginyanu

Affiliations

Tudor Braniste: National Center for Materials Study and Testing. Technical University of Moldova, Stefan cel Mare av. 168, Chisinau, 2004, Republic of Moldova; Corresponding authors at: National Center for Materials Study and Testing. Technical University of Moldova, Stefan cel Mare av. 168, Chisinau, 2004, Republic of Moldova.
Vitalie Cobzac: Laboratory of Tissue Engineering and Cells Cultures. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Polina Ababii: Department of Otorhinolaryngology. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Irina Plesco: National Center for Materials Study and Testing. Technical University of Moldova, Stefan cel Mare av. 168, Chisinau, 2004, Republic of Moldova
Simion Raevschi: Department of Physics and Engineering, State University of Moldova, Alexei Mateevici str. 60, Chisinau, 2009, Republic of Moldova
Alexandru Didencu: Department of Otorhinolaryngology. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Mihail Maniuc: Department of Otorhinolaryngology. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Viorel Nacu: Laboratory of Tissue Engineering and Cells Cultures. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Ion Ababii: Department of Otorhinolaryngology. State University of Medicine and Pharmacy “Nicolae Testemiteanu”, Stefan cel Mare av. 165, Chisinau, 2004, Republic of Moldova
Ion Tiginyanu: National Center for Materials Study and Testing. Technical University of Moldova, Stefan cel Mare av. 168, Chisinau, 2004, Republic of Moldova; Academy of Sciences of Moldova, Stefan cel Mare av. 1, Chisinau, 2001, Republic of Moldova; Corresponding authors at: National Center for Materials Study and Testing. Technical University of Moldova, Stefan cel Mare av. 168, Chisinau, 2004, Republic of Moldova.

Journal volume & issue: Vol. 25

Abstract

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In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFe2O4 nanoparticles. Different quantities of nanoparticles were incubated in vitro with mesenchymal stem cells. High density of nanoparticles (50 μg/ml) leads to a decrease in the number of cells during incubation, while the density of nanoparticles as low as 10 μg/ml is enough to drag cells in culture and rearrange them according to the spatial distribution of the magnetic field intensity. Keywords: Mesenchymal stem cells, Nanoparticles, Gallium nitride, Cells guiding

Published in Biotechnology Reports

ISSN: 2215-017X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.journals.elsevier.com/biotechnology-reports/

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