Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis

Musbah O. M. Tanira; Mehmet Simsek; Khalid Al Balushi; Khulood Al Lawatia; Hameedah Al Barawani; Riad A. Bayoumi

Sultan Qaboos University Medical Journal (Apr 2003)

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis

Musbah O. M. Tanira,
Mehmet Simsek,
Khalid Al Balushi,
Khulood Al Lawatia,
Hameedah Al Barawani,
Riad A. Bayoumi

Affiliations

Musbah O. M. Tanira: Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Mehmet Simsek: Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Khalid Al Balushi: Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Khulood Al Lawatia: Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Hameedah Al Barawani: Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Riad A. Bayoumi: Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.

Journal volume & issue: Vol. 5, no. 1
pp. 9 – 14

Abstract

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Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.

omani, n-acetyltransferase (nat2), genotyping

Published in Sultan Qaboos University Medical Journal

ISSN: 2075-051X (Print); 2075-0528 (Online)
Publisher: Sultan Qaboos University
Country of publisher: Oman
LCC subjects: Medicine
Website: https://journals.squ.edu.om/index.php/squmj/index

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