Apelin aggravates the migration and invasion of non-small cell lung cancer cells via YAP1

Ma Wenchao; Zhu Di; Yu Tong; Xue Junwen; Sun Xiang; Zhang Guofang; Hou Yumeng; Li Jinrui; Chen Yingzhun; Shan Hongli; Liang Haihai

doi:10.2478/fzm-2022-0007

Frigid Zone Medicine (Feb 2022)

Apelin aggravates the migration and invasion of non-small cell lung cancer cells via YAP1

Ma Wenchao,
Zhu Di,
Yu Tong,
Xue Junwen,
Sun Xiang,
Zhang Guofang,
Hou Yumeng,
Li Jinrui,
Chen Yingzhun,
Shan Hongli,
Liang Haihai

Affiliations

Ma Wenchao: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Zhu Di: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Yu Tong: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Xue Junwen: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Sun Xiang: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Zhang Guofang: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Hou Yumeng: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Li Jinrui: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Chen Yingzhun: Department of Pathology, the 2nd Affiliated Hospital, Harbin Medical University, Harbin150081, China
Shan Hongli: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China
Liang Haihai: State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin150081, China

DOI: https://doi.org/10.2478/fzm-2022-0007
Journal volume & issue: Vol. 2, no. 1
pp. 53 – 64

Abstract

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Apelin, an endogenous ligand of G-protein coupled receptor (GPCR), is a secreted peptide involved in the development of various tumors. However, the relationship between apelin and non-small cell lung cancer (NSCLC) is not quite clear. This study was designed to investigate the effect and mechanism of apelin on cell proliferation, migration and invasion of NSCLC cells.

Published in Frigid Zone Medicine

ISSN: 2719-8073 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Special situations and conditions
Website: https://sciendo.com/journal/FZM

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