Infection and Drug Resistance (May 2022)

Distribution and Drug Resistance of Pathogenic Bacteria in Diabetic Patients with Double J-Stent Associated Infections

  • Zeng K,
  • Huang J,
  • Li X,
  • Ye J,
  • Yang J,
  • Zhang S

Journal volume & issue
Vol. Volume 15
pp. 2671 – 2678

Abstract

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Ke Zeng,1 Jun Huang,2 Xiaobin Li,2 Junbing Ye,2 Jian Yang,2 Suchuan Zhang3 1Department of Basic Medicine, Sichuan Vocational College of Health and Rehabilitation, Zigong, Sichuan, People’s Republic of China; 2Department of Urology, First People’s Hospital of Zigong City, Zigong, Sichuan, People’s Republic of China; 3Laboratory Department, First People’s Hospital of Zigong City, Zigong, Sichuan, People’s Republic of ChinaCorrespondence: Suchuan Zhang, Laboratory Department, First People’s Hospital of Zigong City, No. 42, Shangyihao No.1 Road, Ziliujing District, Zigong, Sichuan, People’s Republic of China, Email [email protected]: To analyze the distribution and drug resistance of pathogenic bacteria in diabetic patients with double J-stent associated infections, and to explore the strategies for prevention and treatment of the infections.Methods: From January 2019 to December 2021, 266 diabetic patients treated with double J-stent placement in our hospital assessed for eligibility were recruited. Urine and double J-stent samples were collected for pathogenicity assay and screened for biofilm bacteria. Pathogenic bacteria distribution and drug resistance were examined.Results: A total of 97 strains (36.5%) of pathogenic bacteria were isolated from urine samples and 129 strains (48.5%) from double J-stent samples (P > 0.05). 3 strains (1.1%) of biofilm bacteria were separated from urine samples and 106 strains (39.8%) from double J-stent samples (P < 0.05). In the double J-stent samples, there were significantly higher ratios of Gram-positive bacteria separated from biofilm bacteria versus the urine-cultured pathogens (44.3%/61.3%, P < 0.05), and higher drug resistance was observed in biofilm bacteria versus urine-cultured pathogens (P < 0.05). Fosfomycin tromethamine showed remarkable susceptibility to both urinary cultured pathogens and double J-stent biofilm bacteria.Conclusion: Diabetic patients with double J-stent biofilm-positive bacteria are mainly Gram-positive bacteria, which are prone to biofilm formation and show strong drug resistance.Keywords: pathogenic bacteria distribution, drug resistance, diabetic patients, double J-stent

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