Cytogenetic status and phenotypic properties of lymphocytes of peripheral blood among patients with the Ixodidea mite borreliosis

Abstract

Among patients with acute and chronical clinical course of Ixodidea mite borreliosis there was studied a subpopulation structure and chromosome of peripheral blood lymphocytes, blasttransformation of cells under influence of T- and B-mitogens, production by IL-12 and IL-10 mononuclear leucocytes. Secretion of IL-12 at acute clinical course was increased, IL-10 was depressed, and under chronic clinical course the excretion of both cytoxicants was increased. The level of chromosomal abnormalities in T-lymphocytes was higher in debut of acute period of illness. There was registered the instability of B-lymphocytes genome at the end of acute phase of borreliosis. Deficit of cytotoxic lymphocytes was accompanied by accumulation of cells with caryo-pathology.

Keywords

• лимфоциты
• цитокины
• хромосомные аберрации
• иксодовый клещевой боррелиоз