Nature Communications (Nov 2022)
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis
- Bingzi Dong,
- Masahiro Hiasa,
- Yoshiki Higa,
- Yukiyo Ohnishi,
- Itsuro Endo,
- Takeshi Kondo,
- Yuichi Takashi,
- Maria Tsoumpra,
- Risa Kainuma,
- Shun Sawatsubashi,
- Hiroshi Kiyonari,
- Go Shioi,
- Hiroshi Sakaue,
- Tomoki Nakashima,
- Shigeaki Kato,
- Masahiro Abe,
- Seiji Fukumoto,
- Toshio Matsumoto
Affiliations
- Bingzi Dong
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Masahiro Hiasa
- Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry
- Yoshiki Higa
- Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry
- Yukiyo Ohnishi
- Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences
- Itsuro Endo
- Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences
- Takeshi Kondo
- Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences
- Yuichi Takashi
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Maria Tsoumpra
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Risa Kainuma
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Shun Sawatsubashi
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Hiroshi Kiyonari
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Go Shioi
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Hiroshi Sakaue
- Department of Nutrition and Metabolism, Tokushima University Graduate School of Nutritional Sciences
- Tomoki Nakashima
- Department of Cell Signaling, Tokyo Medical and Dental University
- Shigeaki Kato
- Fukushima Medical University
- Masahiro Abe
- Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences
- Seiji Fukumoto
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- Toshio Matsumoto
- Fujii Memorial Institute of Medical Sciences, Tokushima University
- DOI
- https://doi.org/10.1038/s41467-022-34869-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect on bone itself.
