Nature Communications (Jul 2021)
Identification of 22 susceptibility loci associated with testicular germ cell tumors
- John Pluta,
- Louise C. Pyle,
- Kevin T. Nead,
- Rona Wilf,
- Mingyao Li,
- Nandita Mitra,
- Benita Weathers,
- Kurt D’Andrea,
- Kristian Almstrup,
- Lynn Anson-Cartwright,
- Javier Benitez,
- Christopher D. Brown,
- Stephen Chanock,
- Chu Chen,
- Victoria K. Cortessis,
- Alberto Ferlin,
- Carlo Foresta,
- Marija Gamulin,
- Jourik A. Gietema,
- Chiara Grasso,
- Mark H. Greene,
- Tom Grotmol,
- Robert J. Hamilton,
- Trine B. Haugen,
- Russ Hauser,
- Michelle A. T. Hildebrandt,
- Matthew E. Johnson,
- Robert Karlsson,
- Lambertus A. Kiemeney,
- Davor Lessel,
- Ragnhild A. Lothe,
- Jennifer T. Loud,
- Chey Loveday,
- Paloma Martin-Gimeno,
- Coby Meijer,
- Jérémie Nsengimana,
- David I. Quinn,
- Thorunn Rafnar,
- Shweta Ramdas,
- Lorenzo Richiardi,
- Rolf I. Skotheim,
- Kari Stefansson,
- Clare Turnbull,
- David J. Vaughn,
- Fredrik Wiklund,
- Xifeng Wu,
- Daphne Yang,
- Tongzhang Zheng,
- Andrew D. Wells,
- Struan F. A. Grant,
- Ewa Rajpert-De Meyts,
- Stephen M. Schwartz,
- D. Timothy Bishop,
- Katherine A. McGlynn,
- Peter A. Kanetsky,
- Katherine L. Nathanson,
- The Testicular Cancer Consortium
Affiliations
- John Pluta
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Louise C. Pyle
- Division of Human Genetics, Department of Pediatrics, Children’s Hospital of Philadelphia
- Kevin T. Nead
- Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania
- Rona Wilf
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Mingyao Li
- Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania
- Nandita Mitra
- Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania
- Benita Weathers
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Kurt D’Andrea
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Kristian Almstrup
- Department of Growth and Reproduction, Rigshospitalet
- Lynn Anson-Cartwright
- Department of Surgery (Urology), University of Toronto and The Princess Margaret Cancer Centre
- Javier Benitez
- Human Genetics Group, Spanish National Cancer Centre (CNIO)
- Christopher D. Brown
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute
- Chu Chen
- Program in Epidemiology, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington
- Victoria K. Cortessis
- Departments of Preventive Medicine and Obstetrics and Gynecology, Keck School of Medicine at the University of Southern California
- Alberto Ferlin
- Unit of Endocrinology and Metabolism, Department of Clinical and Experimental Sciences, University of Brescia
- Carlo Foresta
- Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova
- Marija Gamulin
- Department of Oncology, Division of Medical Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine
- Jourik A. Gietema
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen
- Chiara Grasso
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte
- Mark H. Greene
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute
- Tom Grotmol
- Department of Research, Cancer Registry of Norway
- Robert J. Hamilton
- Department of Surgery (Urology), University of Toronto and The Princess Margaret Cancer Centre
- Trine B. Haugen
- Faculty of Health Sciences, OsloMet—Oslo Metropolitan University
- Russ Hauser
- Department of Environmental Health, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Michelle A. T. Hildebrandt
- Department of Epidemiology, University of Texas MD Anderson Cancer Center
- Matthew E. Johnson
- Division of Human Genetics, Department of Pediatrics, Children’s Hospital of Philadelphia
- Robert Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Lambertus A. Kiemeney
- Radboud University Medical Center
- Davor Lessel
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf
- Ragnhild A. Lothe
- Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet
- Jennifer T. Loud
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute
- Chey Loveday
- Division of Genetics & Epidemiology, The Institute of Cancer Research
- Paloma Martin-Gimeno
- Human Genetics Group, Spanish National Cancer Centre (CNIO)
- Coby Meijer
- Department of Medical Oncology, University Medical Center Groningen, University of Groningen
- Jérémie Nsengimana
- Biostatistics Research Group, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University
- David I. Quinn
- Division of Oncology, Keck School of Medicine at the University of Southern California
- Thorunn Rafnar
- deCODE Genetics/Amgen
- Shweta Ramdas
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Lorenzo Richiardi
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte
- Rolf I. Skotheim
- Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet
- Kari Stefansson
- deCODE Genetics/Amgen
- Clare Turnbull
- Institute for Clinical Medicine, Faculty of Medicine, University of Oslo
- David J. Vaughn
- Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Xifeng Wu
- School of Public Health, Zhejiang University
- Daphne Yang
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Tongzhang Zheng
- Department of Epidemiology, Brown School of Public Health, Brown University
- Andrew D. Wells
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Struan F. A. Grant
- Division of Human Genetics, Department of Pediatrics, Children’s Hospital of Philadelphia
- Ewa Rajpert-De Meyts
- Department of Growth and Reproduction, Rigshospitalet
- Stephen M. Schwartz
- Program in Epidemiology, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington
- D. Timothy Bishop
- Department of Haematology and Immunology, Leeds Institute of Medical Research at St James’s, University of Leeds
- Katherine A. McGlynn
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute
- Peter A. Kanetsky
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
- Katherine L. Nathanson
- Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- The Testicular Cancer Consortium
- DOI
- https://doi.org/10.1038/s41467-021-24334-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.
