Nature Communications (Nov 2021)
Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
- Christina M. Termini,
- Amara Pang,
- Tiancheng Fang,
- Martina Roos,
- Vivian Y. Chang,
- Yurun Zhang,
- Nicollette J. Setiawan,
- Lia Signaevskaia,
- Michelle Li,
- Mindy M. Kim,
- Orel Tabibi,
- Paulina K. Lin,
- Joshua P. Sasine,
- Avradip Chatterjee,
- Ramachandran Murali,
- Heather A. Himburg,
- John P. Chute
Affiliations
- Christina M. Termini
- Division of Hematology/Oncology, Department of Medicine, University of California
- Amara Pang
- Division of Hematology & Cellular Therapy, Cedars Sinai Medical Center
- Tiancheng Fang
- Division of Hematology/Oncology, Department of Medicine, University of California
- Martina Roos
- Division of Hematology/Oncology, Department of Medicine, University of California
- Vivian Y. Chang
- Jonsson Comprehensive Cancer Center, UCLA
- Yurun Zhang
- Division of Hematology/Oncology, Department of Medicine, University of California
- Nicollette J. Setiawan
- Division of Hematology & Cellular Therapy, Cedars Sinai Medical Center
- Lia Signaevskaia
- Division of Hematology/Oncology, Department of Medicine, University of California
- Michelle Li
- Division of Hematology/Oncology, Department of Medicine, University of California
- Mindy M. Kim
- Division of Hematology/Oncology, Department of Medicine, University of California
- Orel Tabibi
- Division of Hematology/Oncology, Department of Medicine, University of California
- Paulina K. Lin
- Division of Hematology/Oncology, Department of Medicine, University of California
- Joshua P. Sasine
- Division of Hematology/Oncology, Department of Medicine, University of California
- Avradip Chatterjee
- Department of Biomedical Sciences, Research Division of Immunology
- Ramachandran Murali
- Department of Biomedical Sciences, Research Division of Immunology
- Heather A. Himburg
- Department of Radiation Oncology, Medical College of Wisconsin
- John P. Chute
- Division of Hematology & Cellular Therapy, Cedars Sinai Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-27263-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Ionizing radiation and chemotherapy deplete haematopoietic stem cells and damage the vascular niche. Here the authors show that irradiation induces SEMA3A secretion from bone marrow endothelial cells (ECs), inducing EC apoptosis via NRP1 and that NRP1 inhibition promotes vascular regeneration and R spondin 2 dependent hematopoietic regeneration.
