Nature Communications (May 2020)
Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
- Lindsey S. Treviño,
- Jianrong Dong,
- Ahkilesh Kaushal,
- Tiffany A. Katz,
- Rahul Kumar Jangid,
- Matthew J. Robertson,
- Sandra L. Grimm,
- Chandra Shekar R. Ambati,
- Vasanta Putluri,
- Aaron R. Cox,
- Kang Ho Kim,
- Thaddeus D. May,
- Morgan R. Gallo,
- David D. Moore,
- Sean M. Hartig,
- Charles E. Foulds,
- Nagireddy Putluri,
- Cristian Coarfa,
- Cheryl Lyn Walker
Affiliations
- Lindsey S. Treviño
- Center for Precision Environmental Health, Baylor College of Medicine
- Jianrong Dong
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Ahkilesh Kaushal
- Center for Precision Environmental Health, Baylor College of Medicine
- Tiffany A. Katz
- Center for Precision Environmental Health, Baylor College of Medicine
- Rahul Kumar Jangid
- Center for Precision Environmental Health, Baylor College of Medicine
- Matthew J. Robertson
- Advanced Technology Cores, Baylor College of Medicine
- Sandra L. Grimm
- Advanced Technology Cores, Baylor College of Medicine
- Chandra Shekar R. Ambati
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Vasanta Putluri
- Advanced Technology Cores, Baylor College of Medicine
- Aaron R. Cox
- Department of Medicine, Baylor College of Medicine
- Kang Ho Kim
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Thaddeus D. May
- Department of Pediatrics, Baylor College of Medicine
- Morgan R. Gallo
- Center for Precision Environmental Health, Baylor College of Medicine
- David D. Moore
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Sean M. Hartig
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Charles E. Foulds
- Center for Precision Environmental Health, Baylor College of Medicine
- Nagireddy Putluri
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Cristian Coarfa
- Center for Precision Environmental Health, Baylor College of Medicine
- Cheryl Lyn Walker
- Center for Precision Environmental Health, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15847-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.
