Nature Communications (May 2021)
PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
- Li Chen,
- Qiaoqiao Tong,
- Xiaowen Chen,
- Penglei Jiang,
- Hua Yu,
- Qianbing Zhao,
- Lingang Sun,
- Chao Liu,
- Bin Gu,
- Yuping Zheng,
- Lijiang Fei,
- Xiao Jiang,
- Wenjuan Li,
- Giacomo Volpe,
- Mazid MD. Abdul,
- Guoji Guo,
- Jin Zhang,
- Pengxu Qian,
- Qiming Sun,
- Dante Neculai,
- Miguel A. Esteban,
- Chen Li,
- Feiqiu Wen,
- Junfeng Ji
Affiliations
- Li Chen
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Qiaoqiao Tong
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Xiaowen Chen
- Division of Hematology and Oncology, Shenzhen Children’s Hospital
- Penglei Jiang
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Hua Yu
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Qianbing Zhao
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Lingang Sun
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Chao Liu
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Bin Gu
- Program in Developmental and Stem Cell Biology, Hospital for Sick Children
- Yuping Zheng
- Department of Cell Biology, School of Medicine, Zhejiang University
- Lijiang Fei
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Xiao Jiang
- Department of Biochemistry, Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Wenjuan Li
- Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Giacomo Volpe
- Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Mazid MD. Abdul
- Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Guoji Guo
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Jin Zhang
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Pengxu Qian
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Qiming Sun
- Department of Biochemistry, Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Dante Neculai
- Department of Cell Biology, School of Medicine, Zhejiang University
- Miguel A. Esteban
- Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Chen Li
- Department of Human Genetics, and Women’s Hospital, Zhejiang University School of Medicine
- Feiqiu Wen
- Division of Hematology and Oncology, Shenzhen Children’s Hospital
- Junfeng Ji
- Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-22871-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize pluripotency.
