Chromosome drives via CRISPR-Cas9 in yeast

Hui Xu; Mingzhe Han; Shiyi Zhou; Bing-Zhi Li; Yi Wu; Ying-Jin Yuan

doi:10.1038/s41467-020-18222-0

Nature Communications (Aug 2020)

Chromosome drives via CRISPR-Cas9 in yeast

Hui Xu,
Mingzhe Han,
Shiyi Zhou,
Bing-Zhi Li,
Yi Wu,
Ying-Jin Yuan

Affiliations

Hui Xu: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University
Mingzhe Han: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University
Shiyi Zhou: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University
Bing-Zhi Li: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University
Yi Wu: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University
Ying-Jin Yuan: Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University

DOI: https://doi.org/10.1038/s41467-020-18222-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex genetic traits on a chromosomal scale in yeast.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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